The GFAOP demonstrated that, even in Africa, clinical research could be done prospectively and multicentre. 5 tumor committees, one for each type of cancer, manage clinical studies and care protocol adaptations. Clinical researchers collect data that is analyzed and centralized in Gustave Roussy.
The objective of this medical research program is also to improve knowledge of pediatric cancers in French-speaking Africa : observed incidence of pediatric cancers in pilot units, comorbidities, feasibility of treatments, particular tolerance, treatment efficacy (survival rate, relapse cause, death cause, reasons for non-compliance with treatments, etc).
There are 5 types of cancer that are treated under GFAOP. They account for about 70% of local cancers with a high chance of remission when treated early enough :
  • Nephroblastoma (kidney cancer)
  • Retinoblastoma (eye cancer)
  • Acute lymphoblastic leukemia
  • Hodgkin's disease
  • Burkitt's lymphoma
pathologies repartition

Cancer registry and data management

Since January 2016, with the support of the Sanofi Espoir Foundation, a new patient data collection system has been set up with the objective of improving knowledge of pediatric cancers in the 18 countries (Observed incidence in experimental units, feasibility of treatment, reasons for non-compliance, causes of early death and morbidity). Each unit is asked to register its patients in a common software. Based on this information, new clinical research projects can be conducted to improve treatment protocols.
inclusion repartition per country

Tumor Committees

Burkitt Committee

Coordinator : Siham Cherkaoui (Casablanca, Marocco)
Data manager : Marie-Anne Raquin (IGR, France)
Expert: Catherine Patte (IGR, France)
Members : Maria El Kababri (Rabat), Fousseyni Traoré (Bamako), Chantal Bouda (Ougadougou), Claude Moreira (Dakar)

Nephroblastoma Committee

Coordinator : Claude Moreira (Dakar, Senegal)
Data manager : Brenda Mallon (IGR, France)
Secretary : Jean Jacques Yao Atteby (Treichville, Ivory Coast)
Expert: Catherine Patte (IGR, France)
Members : Pr Mohamed Khattab (Rabat), Sonia Kaboret (Ougadougou)

Retinoblastoma Committee

Coordinator : Fousseyni Traoré (Bamako, Mali)
Expert : Pierre Bey (Curie, France)

Hodgkin Lymphoma Committee

Coordinator : Fatou Binetou Akonde (Dakar), Faten Fedilha (Tunis)
Expert : Odile Oberlin
Members : Laila Hessissen (Rabat), Anissa Trabzi (Alger), Sarra Benmiloud (Fès), Samar Rhayem (Tunis)

Leukemia Acute Lymphoblastic Committee

Coordinator : Pr Guy Leverger
Expert : Guy Leverger (Armand Trousseau hospital)
Members : Françoise Aubier, M'hamed Harif (Casablanca), Boubacar Togo (Bamako), Mame Ndella DIOUF (Dakar), Angèle Pondy (Yaoundé), Mohamed Khattab (Rabat)

The clinical studies conducted since the creation of the GFAOP show encouraging results.

graphic for declared cases

Thus, for Burkitt and nephroblastoma, two successive studies carried out between 2000 and 2009 indicate the following survival rates :

- 60% for Burkitt's Lymphomas (study directed by Professor Catherine Patte from the IGR and Dr Maria El Kababri from Rabat)

- 70% for nephroblastomas (study directed by Professor Catherine Patte from the IGR and Professor Claude Moreira from Dakar)

- For Hodgkin's disease, overall survival was 82% in our 2006-2012 study over 89 cases.

- For acute lymphoblastic leukemias, the latest study conducted by the GFAOP, with the expertise of Professor Guy Leverger from Armand Trousseau Hospital in Paris, shows a disease-free survival rate in sub-Saharan Africa of 60% at the end of the treatment, whose total duration is two years.

- For retinoblastomas, 112 cases have observed in Bamako since the launch of the program in October 2011 with more than 90% healing.

graphique des totaux des cas declarés
graphique recapitulatif | +33 (0)9 72 10 25 44

GFAOP - Gustave Roussy - 114, rue Edouard Vaillant 94805 Villejuif Cedex - France
Cancer Campus Gustave Roussy Cancer Campus Gustave Roussy